MOTS-c

MOTS-c is a mitochondrial-derived peptide (MDP) encoded by the 12S rRNA gene, composed of 16 amino acids. It functions as a metabolic regulator, influencing cellular homeostasis through the activation of AMP-activated protein kinase (AMPK), a key mediator of energy balance. In research lab settings, MOTS-c has demonstrated the ability to modulate mitochondrial biogenesis, enhance oxidative phosphorylation, and regulate glucose and lipid metabolism by promoting the expression of genes involved in these processes.

Experimental findings suggest that MOTS-c can improve insulin sensitivity and increase mitochondrial efficiency in non-human test subjects subjected to metabolic stress. Additionally, MOTS-c has been implicated in modulating oxidative stress response pathways, potentially through its interaction with reactive oxygen species (ROS) and the activation of antioxidant defense mechanisms. Its effects on cellular metabolism and mitochondrial function make MOTS-c a significant candidate for research into metabolic disorders and aging-related pathologies.

Researchers continue to explore its potential as a therapeutic target for modulating mitochondrial function and improving cellular energy production in laboratory settings.